• Take the I-95 S ramp
  
• Merge onto I-95 S
  
• Take I-295 S towards I-295/PORTLAND
  
• Merge onto I-295 S
  
• Take the US-1 S/FOREST AVE/ME-100 S exit- exit number 6A
  
• Merge onto US-1/US-302
  
• US-1/US-302 becomes US-1/ME-100
  
• Turn RIGHT onto STATE ST/US-1 S/ME-77 E
  
• STATE ST/US-1 S/ME-77 E becomes STATE ST/ME-77 E
  
• Turn LEFT onto SPRING ST
  
• 131 SPRING ST

From the south:

• Take the I-95 N/MAINE TURNPIKE NORTH exit towards PORTLAND
  
• Merge onto I-95 N (Portions toll)
  
• Take the I-295 N exit- exit number 6A- towards SO. PORTLAND/PORTLAND DOWNTOWN
  
• Take the US-1 S/FOREST AVE/ME-100 S exit- exit number 6A
  
• Merge onto US-1/ME-100
  
• Turn RIGHT onto STATE ST/US-1 S/ME-77 E
  
• STATE ST/US-1 S/ME-77 E becomes STATE ST/ME-77 E
  
• Turn LEFT onto SPRING ST
  
• 131 SPRING ST